Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter
نویسندگان
چکیده
منابع مشابه
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.
Mitochondria are integral components of cellular calcium (Ca2+) signaling. Calcium stimulates mitochondrial adenosine 5'-triphosphate production, but can also initiate apoptosis. In turn, cytoplasmic Ca2+ concentrations are regulated by mitochondria. Although several transporter and ion-channel mechanisms have been measured in mitochondria, the molecules that govern Ca2+ movement across the inn...
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The Bateson Centre, Department of Biomedical Science, The University of Sheffield, Firth Court, Sheffield, S10 2TN, UK 1) Current address: Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, S10 2RX, UK 2) Current address: Illumina, Inc. Cambridge, CB21 6GP, UK 3) The Sheffield RNAi Screening Facility, Department of Biomedical Science, The University of Sheffi...
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ژورنال
عنوان ژورنال: Science
سال: 2009
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1175145